Advances in Alkylated Chitosan and Its Applications for Hemostasis

Chitosan, a natural polysaccharide, has been widely used as biomaterial, especially for hemostasis. However, hemostatic materials processed from pure chitosan have limited effect and are extremely unstable in some cases; chemical modification is therefore needed to improve the properties of chitosan. Through reactions with hydroxyl amino groups macromolecules, such alkylation, carboxylation, quaternization, etc., different can be introduced into repeating units. Moreover, introduction substituents endow more functions. For example, long alkyl chains its hydrophobic property, greatly property. there still no review alkylated Therefore, we introduce detail several methods (direct reductive alkylation acylation reaction) preparing applications